The Witchblade actress will reprise her role as Red Mist's mother in the Jeff Wadlow-helmed movie, according to The Hollywood Reporter.
Christopher Mintz-Plasse, who portrays Red Mist, recently described Kick-Ass 2 as "super-violent and bloody". His character undergoes a dark transformation in the story following the events of the first film.
Aaron Taylor-Johnson will return as the title character, while Big Daddy actor Nicolas Cage is also rumoured to feature in a cameo role.
Kick-Ass 2's script is an adaptation of both Mark Millar's comic book of the same name and his Hit-Girl spinoff, with the latter series serving as the opening half hour.
Kick-Ass 2 is scheduled for release in May 2013.
Watch a trailer for Kick-Ass below: