The actor admitted he was left exhausted by consecutively filming Mission: Impossible - Ghost Protocol, The Avengers and The Bourne Legacy without a break.
"I've only made it home two weeks in two years. I've been so lucky - I've got to travel to parts of the planet I'd never even heard of. It's been like the blinders coming off," Renner told Glamour.
"It's lonely. I'm doing the most amazing things and couldn't be happier, but I have no-one to share with outside of a director or someone I've just met. So now I'm back in LA after two years and I've just seen my brother and I'm like, 'Where do I begin?'"
Renner added that he is truly enjoying taking some personal time away from work.
"Being focused on my career is important to me. But I'm not so career-orientated I can't balance things," he said.
"I've purposely put my head in a hole and told my agent I need a break. I'll catch up on some movies, do a bit of reading, mend some friendships, see family and friends I haven't seen and slowly integrate back into real life."
Renner's current film The Bourne Legacy topped the US box office over the weekend, knocking The Dark Knight Rises off the top spot.
Watch a trailer for The Bourne Legacy below: