The Detachment star is in talks to replace Gary Oldman as the villain in the new thriller, reports Variety.
Oldman was originally cast in the antagonist role, but it isn't clear why he is no longer attached to the project.
Motor City, starring Gerard Butler, follows a recently-released felon who begins to hunt down the men who framed him.
The film is directed by Albert Hughes and written by Chad St John, and is scheduled for a April 2013 release date.
Brody, who won an Oscar for his lead role in The Pianist, previously revealed that he became "seriously depressed" after he worked on the movie.
He shared: "There were severe transitions that I put myself through physically and emotionally... I shot it when I was 27, and that was my real awakening and entrance into adulthood, that responsibility, and awareness of my own good fortune that I had taken for granted."
Watch the first five minutes of Detachment below: