The Game of Thrones actor will play a werewolf patriarch of small town Lupine Ridge, reports Variety.
Wolves follows an 18-year-old werewolf, played by Lucas Till, who is on the run after the death of his parents and then finds Lupine Ridge.
Wolves marks the feature directorial debut of X-Men writer David Hayter, who also penned the upcoming thriller.
In 2011, Momoa starred in Conan the Barbarian and later denied that he had written a sequel to the movie.
He explained that he had some ideas but "would probably leave it to the writers who are doing it".
Momoa can be seen next in Bullet to the Head opposite Sylvester Stallone, opening in UK and US cinemas on February 1, 2013.
Watch the trailer for Bullet to the Head below: