The picture sees Jean Valjean (Jackman) finding a frail-looking Fantine (Hathaway) on the streets.
The upcoming Tom Hooper film adaptation will also star Russell Crowe, Amanda Seyfried, Samantha Barks, Eddie Redmayne, Sacha Baron Cohen and Helena Bonham Carter.
Hugh Jackman recently described the project as "full on" and "real" due to the actors recording their songs live on set, rather than being overdubbed later.
Les Misérables is out on December 14, 2012 in the US and January 11, 2013 in the UK.
Watch a trailer for the film below:
Les Misérables - photo gallery: