The Bourne Identity helmer has signed on to produce and direct the film based on Olen Steinhauer's espionage novel, reports Deadline.
The book centres around burnt-out spy Milo Weaver, who works for a secret US agency that battles global crime.
A newfound sense of happiness is threatened when he is drawn into the investigation into the death of a hired killer he had been tracking.
The film is expected to be released under a different title following the Angelina Jolie and Johnny Depp-starring 2010 thriller The Tourist.
Liman also directed Go and Mr & Mrs Smith. He is currently shooting the Tom Cruise sci-fi movie All You Need is Kill.