The actress reunites with her Clueless director Amy Heckerling for the comedy-horror, which has Don't Trust the B---- in Apartment 23 actress Krysten Ritter as a co-star.
Silverstone and Ritter play two eternally young vampires struggling to keep their true nature secret while navigating New York's dating scene.
Sigourney Weaver, Malcolm McDowell, Dan Stevens (Downton Abbey) and Justin Kirk (Weeds) round out the cast.
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Vamps will be released in the US on November 2.