Laika's latest animated feature pulls in £1.2 million to hold off competition from Brad Pitt's Killing Them Softly and rise to the number one spot.
The Hunger Games star Jennifer Lawrence's House at the End of the Street earns £796,041 to enter the chart at number three.
Last week's chart-topper The Sweeney falls to number four, while Meryl Streep and Tommy Lee Jones's Hope Springs completes the top five.
Oliver Stone's Savages is the only other new release to make the chart. The drugs drama, starring Taylor Kitsch and Aaron Taylor-Johnson, lands at number 10 with £379,989.
The UK box office top ten in full:
1. (2) ParaNorman - £1,219,194
2. (-) Killing Them Softly - £955,506
3. (-) House at the End of the Street - £796,041
4. (1) The Sweeney - £727,742
5. (6) Hope Springs - £625,201
6. (3) Anna Karenina - £509,196
7. (7) Brave - £468,182
8. (4) Lawless - £413,652
9. (5) Dredd - £382,359
10. (-) Savages - £379,898
Watch the ParaNorman trailer below: