The animated movie sees Count Dracula running a lavish resort where humans and monsters can live together. Gomez provides the voice of the Count's daughter Mavis, who falls for a boy visiting the hotel.
Adam Sandler stars as the voice of Dracula, while Kevin James is Frankenstein. The cast also includes Andy Samberg, Steve Buscemi, David Spade and Cee Lo Green.
Genndy Tartakovsky directed Hotel Transylvania from a script by Peter Baynham and Robert Smigel.
The movie opens in US cinemas on Friday (September 28) and October 12 in the UK.