Burton's upcoming stop-motion animation Frankenweenie reunites Ryder and Burton for the first time since 1990's Edward Scissorhands, in which Ryder starred opposite Johnny Depp.
"I've known Tim Burton for 25 years, and I credit him with my career. I really mean that," Ryder told Flicks and Bits.
She went on to describe her first meeting with Burton for Beetlejuice, during which she failed to realise who he was.
"This guy came in and started talking about movies and music, and 25 minutes later I was like, 'When is this Tim Burton guy coming?' And he was like, 'That's me!'
"And I was like, 'Oh!' I had no idea that a director could actually be so cool and I could easily hang out with them, you know?"
"Our relationship, in a very strange way, it's the same... that love is still there. It's the same Tim Burton from that wonderful day."
Frankenweenie also marks Burton's first collaboration with Martin Landau since 1994's Ed Wood, although Landau made an uncredited appearance in Burton's gothic 1999 horror Sleepy Hollow.
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Frankenweenie will open this year's BFI London Film Festival, prior to its UK release on October 17.
Watch a trailer for the movie below: