The Iron Man 3 and Ender's Game actor is eyeing the role of the villainous king in the tale of the birth of Jesus, reports The Wrap.
The script was penned by The Passion of the Christ co-writer Benedict Fitzgerald and Barbara Nicolosi.
Odeya Rush will play Mary, with Peter O'Toole as Symeon and Julia Ormond taking on the role of Mary's cousin Elizabeth.
Dame Judi Dench is said to be wanted for the role of Anna the Prophetess, and Downton Abbey star Hugh Bonneville for Satan.
In the Biblical story, Herod's downfall was prophesied to come at the hands of the Messiah, prompting him to have all the babies in his kingdom massacred.
Sanctum's Alister Grierson will direct Mary Mother of Christ.