Ryder - who voices Elsa van Helsing in the animated movie - explained that she found Frankenweenie's story of a boy's devotion to his dog to be deeply moving.
"I'm so grateful to be part of this movie Frankenweenie, in particular, because it is so personal to [Burton]," she said, reports Flicks and Bits. "Frankenweenie, it's really about him and his dog. It's a special one, you know?"
She further explained: "There's movies that you do and you talk about them, but then there's the ones that you really love. And all of the three films I've made with Tim Burton I really love, but this one I have to say, I just saw it and I was crying, I was losing it. I loved it.
"I would do anything for Tim, I would read the phonebook and I'm sure he would make it into a brilliant piece of art. I was incredibly touched and humbled that he asked me to be a part of such a personal project. That meant a lot to me."
Frankenweenie is based on a 1984 short film that Burton made prior to his commercial breakthrough Pee-wee's Big Adventure.
Ryder previously gave Burton credit for launching her career with Edward Scissorhands.
Frankenweenie opens on Friday, October 5 in the US and on October 17 in the UK. Watch a clip from the movie below: