Cooper plays a young man who has recently been released from a psychiatric institution. After moving back in with his parents, he meets their similarly unstable neighbour Tiffany (Lawrence) and the two gradually bond.
In the clip, Cooper's Pat and Lawrence's Tiffany compare notes on their various psychiatric medications during a dinner party held by Tiffany's sister (Julia Stiles).
Silver Linings Playbook, which is directed and written by David O Russell, won the top prize at this year's Toronto Film Festival.
Cooper and Lawrence will also co-star in Susanne Bier's upcoming Depression-era thriller Serena, which is set for release next year.
Silver Linings Playbook will be released on November 21.
Watch the trailer below: