The actress, who plays Rosalie, will shortly embark on the global press tour for Breaking Dawn - Part 2.
However, she told E! Online that it will be difficult to cope with the end of the franchise.
"I'm least excited about talking about it being over and coming to an end because it's actually a really sad thought and it's kind of an overwhelming thought," she said.
"I love these movies and I love my character, I love my fans and the cast and all the directors."
Reed also admitted that she is frequently frustrated about not being able to explore the countries she visits while talking about Twilight.
Copyright: Lionsgate/Summit Entertainment"I want to promote the movie, but I also want to see where I'm going and I want to meet the fans and I want to not just be ushered in and out of a hotel room and then be back on a plane to another place," she said.
"I'm doing my very best in each of these countries to see some of where I'm at and experience the culture. It means a lot to me."
Robert Pattinson and Kristen Stewart are expected to reunite for the Breaking Dawn press tour, while the final poster for the franchise was unveiled earlier this week.
Watch a trailer for The Twilight Saga: Breaking Dawn - Part 2 below: