The thriller is a follow-up to 2008's Taken, which also starred Maggie Grace and Famke Janssen.
Hotel Transylvania and Looper also stayed on the top five list on their second week.
Taken 2 knocked out animated film Adam Sandler's Hotel Transylvania to number two spot, which took in $26.3m. Its total gross is now $76m.
Looper, starring Bruce Willis and Joseph Gordon-Levitt, moved down two spots to number four with $12.2m. It has earned a total of $40.3m.
The wide release of Anna Kendrick and Rebel Wilson's musical Pitch Perfect helped the film move from the sixth spot to third place with $14.7 million.
Pitch Perfect debuted last weekend to a limited release, taking in about $5m.
Meanwhile, Tim Burton's new animated film Frankenweenie debuted at fifth place with $11.5m.
End of Watch, Trouble with the Curve, House of the End of The Street, The Master and Finding Nemo (3D) round out the top ten.
The top ten :
1. (-) Taken 2 - $50 million
2. (1) Hotel Transylvania - $26.3 million
3. (6) Pitch Perfect - $14.7 million
4. (2) Looper - $12.2 million
5. (-) Frankenweenie - $11.5 million
6. (3) End of Watch - $4 million
7. (4) Trouble with the Curve - $3.9 million
8. (5) House at the End of The Street - $3.7 million
9. (9) The Master - $1.8 million
10. (7) Finding Nemo 3D - $1.6 million
Watch Liam Neeson talk to Digital Spy about Taken 2 below: