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Photorazzi / David Gabber
The actress - who married Tom Cruise last year - was expected to follow up her performance as Rachel Dawes and is said to have turned down a $2 million deal.
Conflicting reports suggest she was rejected by producers because of her association with Cruise and the controversial Church of Scientology.
"Studios may be gun-shy of her new status as a tabloid fixture," a source told the Daily Mail. "And her expectations may be raised as the new Mrs Cruise.
"Stars of much bigger stature, including Meg Ryan and Demi Moore, have found it tough to regain their momentum after taking time off."
Holmes is said to have signed up for comedy Mad Money instead, while Wedding Crashers star Rachel McAdams is rumoured to be taking over from Holmes in Batman: The Dark Knight.
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