The Wachowskis and Tom Tykwer's new fantasy epic features Berry, Tom Hanks, Jim Broadbent and Susan Sarandon playing multiple roles in a tale that spans millennia.
Discussing Cloud Atlas in a recent interview, Berry said she found the movie to be one of the most intriguing projects of her career.
"I will never be a part of another film like this in my life - I know it," Flicks and Bits quotes her as saying.
She further explained: "Cloud Atlas will always be incredibly special. I'm going to always remember the experience and everything I got from it. I love its originality, the originality of everything.
"There are so many barriers being broken here, so many exciting concepts and, hopefully, it will leave people thinking about how they perceive the world and their own lives."
Her co-star Sarandon recently compared appearing in Cloud Atlas to "being in a circus".
"It was a fun group - Tom Hanks, Halle Berry - they gave themselves over to the big ideas in the film," Sarandon said. "I was so tickled they brought me over to do a bunch of little parts. It was insane in the best way possible."
> Cloud Atlas cast talk multiple storylines in new featurette - watch
Cloud Atlas opens in the US on October 26, 2012 and in the UK on February 22, 2013. Watch a trailer for the movie below: