The actress said that she is keen to reprise her role as Liz Sherman in the unconfirmed sequel.
Blair told Bloody Disgusting: "It's my dream to work with Guillermo del Toro again. I just want to be near him. I love him. I miss him.
"It's my dream that one day when I'm done with [Anger Management] they say, 'Ok the movie's actually going to go!' That would be the biggest heaven.
"I mean it's all set up. Hellboy 3 is the biggest payoff and the biggest horror. I want to see what these twins are up to, if one's the devil and one's an angel. I want to see what Hellboy and Liz are up to!
"I know the film is the apocalypse and the apocalypse isn't cheap to shoot so we have to find some funding and get going with it!"
While Hellboy creator Mike Mignola has greatly downplayed the chances of a third film, del Toro and star Ron Perlman are apparently more optimistic.
The director recently said that they are seeking financing for Hellboy 3.