The Castaway star explained that the multi-thread plot of both films challenges the audience.
"There are going to be people out there who are going to say, 'Who do they think they are to make this movie like this?'" he told The Belfast Telegraph.
"That's been the case with every great film. I think every audience is yearning to be surprised. I am bored when I walk into the theatre expecting A, B and C, and a movie delivers A, B and C.
"I want to see something brand new that I never anticipated coming a hundred million miles away," he continued, "And my God, that happens before the words 'Cloud Atlas' appear up on the screen on this one."
Speaking to the Chicago Sun-Times, Hanks added: "I loved that it wasn't going to be simple for audiences.
"Lord, doesn't that sound beautiful? A film that is original, creative and makes you think. That's what movies used to be.
"I think it's as risky as Inception," he concluded.
"Inception was a complete one-off. You saw it the first time and said, 'How many movies are in this thing?'"
Cloud Atlas stars Tom Hanks, Halle Berry and Jim Broadbent playing multiple characters across multiple chronologies. The film was directed by Tom Tykwer (Run Lola Run) and Lana and Andy Wachowski (The Matrix trilogy) and opens in the US on October 26 and in the UK on February 22, 2013.
Watch a Cloud Atlas featurette, exclusive to Digital Spy, below: