The Paperboy actor will take on the lead role of Clayton Riddell, an American artist attempting to reunite with his son following an apocalyptic event.
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Cell's plot sees the majority of the world's population turned into mindless, vicious animals by a mysterious signal transmitted over mobile phones.
The Last House On The Left scribe Adam Alleca co-wrote the screenplay with King, and Cargo Entertainment are on board to produce the project, reports Screen Daily.
Cusack previously starred in another King adaptation, 1408, alongside Samuel L Jackson. The movie is considered one of the better films inspired by the author's work.
A director for Cell is expected to be appointed soon.
Watch a trailer for 1408 below:
