The film stars Rooney Mara, Channing Tatum and Catherine Zeta Jones, in her third collaboration with the director.
Yahoo Movies has released the first trailer for the film, a psychological thriller set in the world of the pharmaceutical industry.
The film follows a troubled woman who attempts to cope with the imminent release of her husband from jail by taking a new prescription drug, which leads to tragic, unforeseen consequences.
Rooney Mara stars in the lead role, after replacing original star Blake Lively. The script is written by Contagion and The Informant! screenwriter Scott Z Burns.
Side Effects will be released in the US on February 8, 2013, and March 15 in the UK.
Watch the new trailer below: