The actor reprises his role as werewolf Jacob in the final film The Twilight Saga: Breaking Dawn - Part 2 along with co-stars Robert Pattinson and Kristen Stewart.
In an interview with Reuters, Lautner spoke about moving away from the role that made him an international star.
"These characters have never stopped changing throughout the entire franchise, and that's what I love about Jacob," Lautner said. "Jacob himself has grown up so much and gone through so many hurdles and it was a fantastic character to play."
He continued: "For me, it'll be tough to say goodbye to spending time with people that I love. We've grown so close over the past few years. Our relationships will go on past this but to not have that excuse to spend day after day together while filming or promoting will be different."
Lautner went on to express hope that Twilight's loyal fanbase will be pleased with the franchise's conclusion.
"I just hope they're happy and they're proud because we really do make these movies for them," the star explained. "They're the reason we are able to make them, their support is unreal and we're so proud of this last one. This last one specifically wraps it up so nicely, it's an amazing movie.
"During the movie, it'll keep you on the edge of your seat but by the end, I think more than a few of the fans will be in tears."
Lautner previously revealed that he sought advice from Twilight author Stephenie Meyer on how to play the series' "imprinting" storyline.
The Twilight Saga: Breaking Dawn - Part 2 will open in cinemas on November 16. Watch a trailer below: