The actor has been linked with the part of Harry Osborn in the superhero movie, and is said to be up against Brady Corbet and Alden Ehrenreich for the role.
"You know, I would love to be in Spider-Man. I have a lot of respect for Andrew Garfield as a person and an artist and a lot of respect for Marc Webb as a person and an artist," he told Crave Online.
"If that opportunity were to come along, I would be really flattered and humbled to be a part of it. But that's about it for now I guess."
However, DeHaan was tight-lipped when asked whether he had already auditioned for the part.
"Well, I know there's a lot of names being tossed around and rumours and stuff, but again, it's a project I would love to do and if the opportunity would come along and the offer would come along, I would love to do it," he explained. "Until then, I don't think it's worth speculating or creating rumours."
Photo gallery - Marvel Spider-Man movies in pictures:
Shailene Woodley was recently confirmed to be joining the Marvel Comics-based sequel as Mary Jane Watson alongside returning stars Emma Stone and Andrew Garfield.
The Amazing Spider-Man 2 is scheduled to arrive in cinemas on May 2, 2014.
Watch the trailer for The Amazing Spider-Man below: