The Mad Men actor is eyeing the Kevin Costello-penned comedy, which will be directed by Mark Teitelman, according to Variety.
The movie centres around a down-on-his-luck teacher who hires two students to kidnap his wife.
His attempt to stage a rescue and rekindle their marriage presumably does not go entirely to plan.
Costello has lined the project up for producers Sheldon Turner and Jennifer Klein, who will also be working on his rewrite of Six Month Curse.
The latter film tells the story of a bride who discovers that she is under a curse which means that every romantic liaison she enjoys will end after six months.
Hamm has previously avoided starring roles outside of Mad Men, but will also take the lead in the forthcoming Disney movie Million Dollar Arm.
Watch a trailer for Hamm's Friends with Kids, released earlier this year, below: