He will star alongside Elizabeth Banks in the comedy, reports ComingSoon.net.
Steven Brill wrote and will direct the movie about a highly-strung news anchor (Banks) who finds herself locked out of her flat after a heavy night of drinking.
With no money, ID, telephone or keys, she embarks on a series of misadventures as she attempts to get to a very important job interview on time.
Marsden has recently been linked to a potential role in Marvel Studios' Guardians of the Galaxy and a return as Cyclops in X-Men: Days of Future Past.
His upcoming movies include Lee Daniels's The Butler - in which he will play John F Kennedy - and The Loft.