The movie sees Johnny Depp reunite with Pirates of the Caribbean director Gore Verbinski and producer Jerry Bruckheimer to play Tonto, the Native American ally of Armie Hammer's lawman John Reid.
Verbinski said of his fifth collaboration with Depp: "I have always been intrigued by characters who exist at times of monumental change.
"With no well defined beacons to aid them, and no tribe to return to, they are a glorious pair of misfits: A band apart."
Tom Wilkinson also features as villain Latham Cole, while Helena Bonham Carter, William Fichtner, Barry Pepper, James Badge Dale and Ruth Wilson are among the supporting cast.
Jack White will write, produce and perform the score for the Disney blockbuster Western, making it his first major musical contribution to a feature film.
The Lone Ranger will open in cinemas worldwide in summer 2013.
Photo gallery - 'The Lone Ranger' in pictures: