The ceremony will be the first time Adele has performed 'Skyfall' live and marks her first US TV performance since the Grammys last year.
"It's an honour to be nominated and terrifyingly wonderful to be singing in front of people who have captured my imagination over and over again," Adele said. "It's something I've never experienced and probably only ever will once!"
'Skyfall' won a Golden Globe earlier this month and is the first James Bond theme to be Oscar-nominated since Sheena Easton's 'For Your Eyes Only' in 1981.
"We have enormous respect for Adele's unique artistry as a songwriter and a singer," said show producers Craig Zadan and Neil Meron.
"She is currently one of the most successful recording artists in the world, and we believe that her performance of 'Skyfall' will be an exciting Oscar moment for audiences watching at the Dolby Theatre and on television screens around the world."
This year's Oscars will feature a special tribute to James Bond to mark the character's 50th anniversary on the big screen.
It is rumoured that the Academy is trying to get all six 007 stars - Sean Connery, George Lazenby, Roger Moore, Timothy Dalton, Pierce Brosnan and Daniel Craig - to appear together as part of the celebration.
The 85th Academy Awards will take place on February 24.
Photo gallery - Oscar nominees in pictures: