A Many Splintered Thing helmer Justin Reardon will direct the project, which is due to enter production this summer.
Convention, described as a "mind-bending comedy", sees Aniston and Dupliss change the box storage world with the invention of a five-sided box, creating inter-dimensional molecular mayhem and threatening the very existence of the universe in the process.
"Convention is a wildly original and funny screenplay. Justin Reardon's approach to the material is bold, inventive and bursting with imagination," said producer Paul Schiff.
"Finally, we could not be more thrilled to have such a gifted group of actors on board to bring this film to life."
Convention, based on a screenplay by Christopher Painter, is yet to be assigned a release date.