The Knocked Up actress will take the lead role in The Sessions director Ben Lewin's romantic drama, according to The Hollywood Reporter.
The film centres around a fashion designer who develops a disease that begins to damage her memory.
He husband struggles to capture the last pieces of their love before it is all gone.
The movie is based on Korean television series Pure Soul, which was itself adapted into a film in 2004.
Heigl was most recently seen in One for the Money, and will next appear alongside Robert De Niro, Diane Keaton, Amanda Seyfried, Topher Grace, Susan Sarandon, Robin Williams and Ben Barnes in The Big Wedding.
A Moment to Remember will begin shooting in the spring.