The final instalment of the series was named 'Worst Picture' and 'Worst Remake, Rip-off or Sequel', with the cast picking up 'Worst Screen Ensemble'.
Kristen Stewart took home the 'Worst Actress' award for her role in the film, as well as her performance in Snow White and the Huntsman.
She did not attend the spoof award ceremony in LA, with a cardboard cut-out of her accepting the prize on her behalf.
The latest Twilight film - which contributed to the series's $3bn (£1.9bn) box office takings - also won 'Worst Director' for Bill Condon and 'Worst Supporting Actor' for Taylor Lautner.
Lautner and Mackenzie Foy were named 'Worst Screen Couple' by the Razzies, which celebrate "the worst that Hollywood has to offer each year".
Elsewhere, Rihanna won 'Worst Supporting Actress' for her debut film role in Battleship, while Adam Sandler received 'Worst Actor' for his role in That's My Boy, which also won 'Worst Script'.
Watch a trailer for The Twilight Saga: Breaking Dawn - Part 2 below: