In the short clip, James Franco, Seth Rogen, Jay Baruchel and Danny McBride show how they celebrated 4/20.
4/20 is a phenomenon associated with cannabis culture, where people smoke the drug at 4.20pm on April 20.
This is The End follows six friends who are trapped in a house during the apocalypse.
It also features Rihanna, Emma Watson, Paul Rudd, Jonah, Hill, Jason Segel, Michael Cera and Mindy Kaling.
This Is the End will be released on June 12 in the US and June 28 in the UK.