Filmed in just 12 days in between The Avengers' end of production and beginning of post-production, Much Ado stars Denisof and Acker as sparring lovers Beatrice and Benedick, and has already enjoyed a strong box office opening in the US.
Digital Spy sat down with Whedon to discuss romantic comedies, reuniting Angel stars Denisof and Acker, and what Shakespeare play he'd like to tackle next.
Watch more extracts from our interview with Whedon, in which he discusses The Avengers 2, Buffy the Vampire Slayer and Star Wars.
Much Ado About Nothing also stars Nathan Fillion, Sean Maher, Clark Gregg, Reed Diamond, Fran Kranz, Jillian Morgese and Tom Lenk.
The film is released this Friday, June 14 in the UK.