The video sees Danny Trejo's titular gun for hire dispatching his foes in a series of ridiculously grisly scenes.
Watch the trailer below (Warning: Explicit content):
Robert Rodriguez's tongue-in-cheek action sequel sees Machete hired by the President of the United States (Charlie Sheen as Carlos Estevez) to assassinate a charismatic and insane arms dealer (Mel Gibson).
Michelle Rodriguez, Amber Heard,, Lady Gaga, Antonio Banderas, Jessica Alba, Demián Bichir, Alexa Vega, Vanessa Hudgens, Cuba Gooding Jr, William Sadler and Marko Zaror also feature in the movie.
The original film began life as a spoof trailer at the beginning of Rodriguez's Planet Terror.
Machete Kills will open at US cinemas on October 4 and in the UK on October 11.