Patton and the Fruitvale Station actress will make the announcement from The W Hollywood on Tuesday, November 26.
Film Independent president Josh Welsh said in a statement that it will be "a pleasure" for his organisation to have Patton and Spencer reveal the nominees.
"This is an important moment in the independent film community calendar and we are delighted they will be with us as we announce the nominees for the year's top independent films and artists," Welsh commented.
The 2014 Independent Spirit Awards will be held on Saturday, March 1 in Santa Monica, CA. IFC will air the ceremony on tape delay.
Last year's ceremony saw Silver Linings Playbook sweep the 'Best Film' and 'Best Screenplay' categories.
David O Russell took 'Best Director' for the romantic drama, while Jennifer Lawrence was the recipient of the 'Best Female Lead' Award.
Lawrence went on to win the 'Best Actress' Oscar for Silver Linings Playbook.
Watch a trailer for the Independent Spirit Award-winning film Silver Linings Playbook below: