The actor-producer will be given the Trailblazer Award by his Jupiter Ascending co-star Mila Kunis at the April 13 ceremony.
American Hustle, Wolf of Wall Street lead MTV Movie Awards nominations
MTV president Stephen Friedman hailed Tatum as a true Hollywood innovator in a statement announcing the award.
Friedman said: "Channing Tatum is the quintessential leading man for the MTV audience. He proves that an action hero can have both a quick wit and a large heart.
"Whether he's baring his soul in The Vow, his chest in Magic Mike, or his humour in 21 Jump Street, Channing proves that by committing everything, you can accomplish anything."
The Trailblazer Award has previously been given to Emma Stone and Emma Watson.
Mark Wahlberg will also receive a career salute at the gala, with Ellie Goulding and Zedd lined up as musical performers.
The 2014 MTV Movie Awards will be hosted by Conan O'Brien from the Nokia Theatre in Los Angeles on April 13.
Watch a trailer for Jupiter Ascending below: