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The actor said the forthcoming movie, in which he plays the Hulk's alter-ego Bruce Banner, was "definitely intended as chapter one".
He also revealed that he was initially sceptical about taking the role, telling Total Film: "When the phone rings and someone says, 'Hey, would you be interested in the big green guy?' there's that part of all of us that doesn't want to look like an idiot. There's the wince factor or the defensive part of you that recoils at what the bad version of what that would be. And I did that, basically. I said 'no' to it a couple of times."
He insisted that the new movie will bear no relation to the 2003 version starring Eric Bana, saying: "I think like Chris Nolan and those guys did with Batman, we just said: 'We're going to start completely with our own version of this myth or saga.'"
Co-star William Hurt recently confirmed that there were crossovers between The Incredible Hulk and new film Iron Man, both of which are based on Marvel Comics creations.
The Incredible Hulk is scheduled to hit UK cinemas in June.
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