Karyn Kusama will direct the movie which tells the story of a possessed cheerleader who begins to feed off boys in a small Minnesota farming town.
Former OC star Brody will play Nikolai, the evil frontman for a rock band. Simmons has been cast as high school science teacher Mr Wroblewski.
Transformers actress Megan Fox is already on board to play the cheerleader while Amanda Seyfried will play her nerdy best friend.
Juno director Jason Reitman will produce the film.