The company will adapt the futuristic cop thriller into a 3-D live-action movie, according to Variety.
Written by Masamune Shirow, the plot follows the lives of Japanese National Public Safety Commission workers, who battle technology-related crime.
Steven Spielberg was behind DreamWorks' bid for the project. He said: "Ghost in the Shell is one of my favourite stories. It's a genre that has arrived and we enthusiastically welcome it to DreamWorks."
Jamie Moss will write the adaptation, while Avi Arad and Steven Paul are expected to produce the film.
Ghost in the Shell, which was first published nearly 20 years ago, has already spawned three anime films and a trio of video games.