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Ealing Studios described St. Trinian's: The Legend of Fritton's Gold as a cross between The Goonies and The Da Vinci Code.
Oliver Parker and Barnaby Thompson will again direct, while writers Piers Ashworth and Nick Martin will return to pen the script.
Speaking at the Cannes Film Festival, Thompson said he hoped cast members Gemma Arterton, Russell Brand and Rupert Everett will also reprise their roles.
He told Variety: "It would be good to get the old gang back in."
The fifth instalment of the series was a box office success last year.
Filming on the sequel is scheduled to begin next January.
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