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Other cast members include Chris Parnell, Cheryl Hines, Luke Kirby and Connie Britton. Lara Shaprio helms the project.
Lohan will play an assistant at a publishing house, who feigns a pregnancy to avoid being fired by her boss, reports Variety.
Speaking about the role, the actress said: "It is a very different role for me and I look forward to the challenges it will present, and I love working on comedies."
It is due to begin shooting later this month.
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