Rumours have been rife that the actor is to step down from the franchise, with Patrick Fugit and Michael Angarano said to be the frontrunners to take over the role.
However, J.K. Simmons, who plays newspaper chief J. Jonah Jameson, said Maguire has not ruled out a return.
He told IESB: "I spoke to Tobey in, I guess it was February, and he's certainly amenable to doing some more.
"Hopefully we'll be able to get everybody back and make another good one."
> Spider-Man sequels to film back-to-back?