The stars, who play Blair Waldorf and Vanessa Abrams, told MTV News that they would jump at the opportunity to turn the Manhattan-based drama into a movie.
"A Gossip Girl movie could be compared to a Sex And The City-type of movie. I think that would be kind of hot," suggested Meester.
"We'll see what happens. There's no resolution in each episode - it's always a cliffhanger. So it would be pretty juicy as a movie."
Szohr went on to joke that because the CW show is based on a book series, producers "might as well just check off the list and make it a film too".
However, she admitted that a potential Gossip Girl movie would not be possible for "a couple more years", adding: "We're just going into the third season. But I think it'd be fun, we'd all be excited to do it."
Szohr is currently filming horror remake Piranha 3D, while Meester is working on thriller Roommate alongside Twilight's Cam Gigandet.