To promote the double-disc collection, Mac also heads up the Annie Mac Presents 'All The Way' tour next month, with guests Magnetic Man, Redlight, Rudimental and Disclosure.
After quizzing her about pal Nick Grimshaw's new job as the Radio 1 Breakfast Show host, we went on to ask her about dance music, DJing and more.
How much fun is to make the compilations?
"It's really fun. It's just like making a mixtape. One of my favourite things is putting mixes together, putting songs together, making playlists on iTunes or whatever, so this is like a glorified, professional version of that. It's a genuine reflection of the songs that I've connected to most in the year.
"CD One is a real direct reflection of what I've been playing out in festivals, it's pretty much the setlist of my festival sets. CD Two - if I was playing in the back room of a basement club, that's what I'd play. But I don't really get to do those things that often so it's kind of weird and self-indulgent."
Do you get any faff with tracks that you want to put on but can't?
"Well there's only been a couple with this that I really wanted to put on that I wasn't able to and that is all the Roc Nation stuff. Rihanna 'We Found Love', which is my favourite pop song of the year, we weren't allowed to have that. Also 'Paris' by Jay-Z and Kanye, they wouldn't let that - I'm really happy we got stuff like A$AP Rocky and Frank Ocean and Azealia Banks."
'212' is on the compilation, what do you think about Samantha Cameron apparently being a fan?
"My favourite tweet about that was my friend Sophie Wilkinson who said, 'I can't believe SamCam likes a song that says 'I guess that c**t went to Eton' (sic). It's brilliant innit. But yeah - big up Sam Cam, I've got nothing to say!"
How do you feel 2012 has been for music?
"I feel like it's been brilliant, it's never been such a good time for dance music. Dance music has become so ubiquitous and in a way it's become pop music. When it becomes that popular it just makes a much bigger awareness for the more underground stuff.
"Disclosure, for instance - four years ago when I did the comp they wouldn't have been on the Radio 1 playlist but are now supported by mainstream radio, I find that really exciting. It's been a good year for underground music to be accepted and accessible to everyone.
"It's also been a year of no boundaries in terms of genres. There's so many producers coming through like Disclosure or AlunaGeorge, who are influenced by R&B and garage and lots of different genres, and you can hear all that within their music.
"I feel like it's been a great year. It's been great year for house music as well. House music's got bigger than ever and the second disc hopefully reflects that a bit."
If you were forced to pick one standout that is maybe less well-known, what would it be?
"We commissioned in some brand new music - exclusive tunes for the comp and there's a tune by Melé on there called 'Spacejam'. Melé is a 19-year-old guy from Liverpool, super young, super-talented, one of those genre-hopping guys I was telling you about, he'll play everything from grime to jungle to hip-hop. Everything in his set just hops from sound to sound brilliantly.
"He's a super-talented producer as well, it's basically trap music, which is the new thing that everyone's talking about, but it's very much his slant on trap music - and it's completely original, you only hear it on the comp, and it's just a real nice opportunity to be able to support people like that."
Has the web encouraged that sort of eclecticism?
"Completely, it's so immediate - the way music is put out there and consumed. People don't consume long-players as much as they used to. They just pick their favourite track from here and here and they just kind of put together their own things that they like and Spotify them or whatever, or they listen to stuff on YouTube, which has become weirdly the new kind of radio.
"It's good for me because I can represent sounds from everywhere and put them together, but that was the other reason why we got exclusive music on the comp because you need to give just more than a selection of music. People get that everywhere, they make their own comps. Hopefully having music that you won't hear anywhere else on this is more of an incentive to invest in it."
Jessie Ware's on the disc - and she's got a Mercury nomination - what do you make of this year's shortlist?
"I think it's great, it's quite indie actually. There's a lot of really good quality indie bands on there, you know like Django Django and The Maccabees and stuff. I think it's great, I think it's always great, yeah, I hope she wins."
It's been criticised for being pedestrian...
"Yeah, there's always curveballs in the Mercury playlist and there's always a weird jazz musician. I mean, to be honest with you, I haven't like studied it so much to be really commenting on it, but there's a few that have stuck out at me."
And Jessie's your tip?
"I don't know if she'll win, but it's who I would like to win."
How different will your sets be on your All The Way tour to your usual dates?
"It's pretty much like I would do my normal DJ set. The nice thing after DJing at festivals and Ibiza and the more summery sets is that when you come back and play in the UK, you can really go all out and play different music and play underground music and know that it will be embraced by people.
"I'm looking forward to doing that and playing tons of new stuff, and that's what this will be about, it's about kind of finding the new bangers for next year, that's what we're doing sort of touring like just experiments a lot and play new sounds.
"Having that lineup, the strength of that lineup behind you really pushes you and it pushes everyone else to be the best that they can be, so it makes it exciting."
Do you get to enjoy the other acts or are you too much in the zone of your own set?
"No, you definitely get to enjoy everyone else. That's the whole point of AMP for me. You get to see other DJs that you respect and you get to learn from them and maybe hear new music from them and have a laugh with them. It's another important bit."
Are other Radio 1 DJs like Zane Lowe and Chris Moyles treading on your turf with their tours?
"Not really, not at all. I feel like anyone who is a DJ on Radio 1 is gonna have an opportunity to go and play records and make money out of that... We've always been really careful to play for the people that we respect, the promoters who promote like underground music.
"A lot of the Radio 1 DJs will just go and play freshers' balls and I will do that the odd time, but my main DJing is for underground clubs and I think that's the way I'll keep it."
Would you say yes to Simon Cowell's reality TV DJ show if it ever happened?
"I would have an immediate problem with it because you can't judge anyone playing records until you go and see them doing a full set in a club, and they're not obviously going to be able to put that on a television show.
"For that reason I automatically disagree with the format. It sounds like it's going to be one of those, if it ever happens, 'who can perform the most' rather than who can select the best, and I think that that's a line that's becoming more and more blurred in DJing today.
"It's more about standing on the decks and f**king crowd surfing and throwing things in people's faces and doing heart signs. It's become so much about performance.
"Dance music has got so big now that DJs are playing stadiums, so you have to give more. I'll still be all about being in a corner not seen and just playing music. That for me is the ultimate goal."
Annie Mac releases Annie Mac Presents 2012 on October 8. It is available for pre-order now.
She takes the AMP 'All The Way' tour on the road in November and December, with guests Magnetic Man, Redlight, Rudimental and Disclosure.