'Greatest Day', the lead single from the group's upcoming album The Circus, debuts in the top spot this week. It becomes the group's third number one in five attempts since reforming in November 2005.
Last week's chart-topper, 'If I Were A Boy' by Beyoncé, falls to two, while T.I. and Rihanna climb to three with 'Live Your Life'.
Britney Spears bounces back to seven with 'Womanizer' following her performance on The X Factor, while Akon climbs to nine with 'Right Now (Na Na Na)'.
Meanwhile, singles by Same Difference and McFly both fall short of the top ten, debuting at 13 and 18 respectively.
Britain's Got Talent champion George Sampson also makes a disappointing chart debut, stalling at 30 with 'Get Up On The Dancefloor' / 'Headz Up'.
The top ten singles in full (click to read our reviews):
1. (-) Take That: 'Greatest Day'
2. (1) Beyoncé: 'If I Were A Boy'
3. (4) T.I. ft. Rihanna: 'Live Your Life'
4. (3) The Killers: 'Human'
5. (5) Katy Perry: 'Hot N Cold'
6. (6) Alesha Dixon: 'The Boy Does Nothing'
7. (9) Britney Spears: 'Womanizer'
8. (2) 'X Factor' Finalists 2008: 'Hero'
9. (14) Akon: 'Right Now (Na Na Na)'
10. (7) Girls Aloud: 'The Promise'
Source: Official Chart Company
> Click here for this week's UK albums chart