Kings of Leon narrowly miss out on scoring a second consecutive chart-topper, climbing from ten to two with 'Use Somebody'.
The highest new entry of the week is 'Little Drummer Boy/Peace On Earth', a single recorded by Aled Jones and Sir Terry Wogan in aid of Children In Need.
Britney Spears falls to four with 'Womanizer', while Take That slip to five with former chart-topper 'Greatest Day'.
Outside of the top ten, notable gains come from James Morrison, who climbs from 31 to 18 with 'Broken Strings', and Boyzone, who leap from 56 to 22 with 'Better'.
The top ten singles in full (click to read our reviews):
1. (1) Leona Lewis: 'Run'
2. (10) Kings of Leon: 'Use Somebody'
3. (-) Bandaged: 'Little Drummer Boy/Peace On Earth'
4. (3) Britney Spears: 'Womanizer'
5. (2) Take That: 'Greatest Day'
6. (8) Akon: 'Right Now (Na Na Na)'
7. (5) The Killers: 'Human'
8. (4) Katy Perry: 'Hot N Cold'
9. (6) Beyoncé: 'If I Were A Boy'
10. (7) T.I. ft. Rihanna: 'Live Your Life'
Source: Official Chart Company
> Click here for this week's UK albums chart