The recently-reformed dance legends will follow last year's bill-toppers Iggy and the Stooges as headliners of the one-day event.
Band member Paul Hartnoll said: "We're really excited to be playing at Get Loaded.
"It should be a fantastic way to end the summer festival season and we've heard some great reports from friends who have been. It's brilliant to be playing a big outdoor show in London."
Get Loaded In The Park takes place on Clapham Common on August 20.
Orbital were recently confirmed as the headliners for the Saturday night at the Rock Ness festival in Scotland.