The 'Womanizer' singer, who starts the second North American leg of her 'Circus' world tour later this month, is nominated for three gongs at the ceremony, held at Universal City's Gibson Amphitheatre in California.
Britney's performance will mark a decade since she sang debut single '...Baby One More Time' at the first Teen Choice Awards in 1999.
Sean Kingston, Miley Cyrus and the Black Eyed Peas are also expected to perform at the event, which is hosted by the Jonas Brothers.
Vampire thriller Twilight is the favourite to pick up most awards after it was recognised in 12 categories.
Robert Pattinson and Kristen Stewart are up for Choice movie actor and actress in the drama category, while Cam Gigandet is in the running for the Choice movie villain.