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In an interview with The Sun, the 46-year-old explained that GaGa is what she calls a "meteor - singers who entertain people for a while".
She said: "Hey, there's nothing wrong with that. But then there are people like Neil Young who show up at Glastonbury 40 years into their career. And that's a very different kind of artist. Neil Young doesn't have to get his bum out on stage!
"The question is, will Lady GaGa be playing alongside Neil Young at Glastonbury in 20 years time?"
She added: "She wants to entertain people. Right now, half the world is depressed and they need to be entertained. So her timing's perfect."
Amos recently announced details of a short UK tour for September, supporting the release of her tenth studio album Abnormally Attracted To Sin.
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