Music
Rex Features
The area will be closed off as the group mark the tenth year of the event, as well as the first anniversary of Absolute Radio and their own 30th birthday.
Frontman Suggs told the station: "What a great joy. Who would have thought it, when I left school with no qualifications whatsoever, that I personally would be in charge of blocking off all of Regent Street?
"Madness will be performing with some other great live acts, right at the far end of Regent Street, hopefully to thousands of very happy people."
He added: "I'm hoping that we'll be playing loud enough so that more than the chosen few will be able to hear what's going on."
Earlier this year, Madness played a concert on an open-topped bus in Inverness Street, Camden Town as part of the Camden Crawl festival.
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