The annual dance event kicks off on September 23 with a special preview show featuring Maximo Park and ends on New Year's Day 2011 with an as-yet unannounced line-up.
Organisers said: "As ever the line-up has been pieced together since before the doors closed on the last series, and right up until today we've been pushing every DJ and live act worth their salt to get on board.
"We hope you enjoy what lies ahead, and hope to see you venture beneath the streets to celebrate Five Years of The Warehouse Project."
Kelis, Calvin Harris and Starsmith play the Welcome To The Warehouse event on October 2. October 16 sees Doves headline with support from Steve Mason, Field Music and Mike Pickering.
Delphic present their debut album Acolyte on October 30 with support from The Whip. Pete Tong and Riva Starr top a WHP special on November 4.
Sub Focus, DJ Yoda and Roni Size play Metropolis Birthday on November 6. Resident Advisor Present sees Booka Shade and Carl Craig on November 12. John Digweed and Josh Wink play the Bedrock night on November 19.
Vitalic top the bill of the Chibuku Shake Shake night on November 27, while Simina Mobile Disco and Hercules & Love Affair perform the SMDs Delicatessen on December 3.
December 12 sees a night of Modselektion, featuring Moderat, Modeselektor DJS and Clark. Former Stone Roses frontman Ian Brown headlines on December 17 with support from Scratch Perverts. Sasha plays V_rtek on December 18, with David Guetta topping the bill the next day.